“Metabolic regulation of T cell signalling and function during ageing”

Host: Dr Henry McSorley, Dr Andy Howden & Dr Linda Sinclair  

Venue: Sir Kenneth & Lady Noreen Murray Seminar Room, CTIR 284

This Seminar is fully funded by external sources  

Abstract  

Joy Edwards-Hicks’ group investigates how age-related metabolic changes impact lymphocyte signalling and function. An emerging body of data suggests that organismal lipid metabolism plays an important role in the ageing process. In humans, lipids in the blood are used as biomarkers of age-associated diseases, and lipid-centric dietary, pharmacological, genetic, and surgical interventions extend lifespan in model organisms. The human immune system functionally declines with age, but how the organismal lipid environment impacts cellular lipid homeostasis and T cell function is not well understood. The goal of their research is to promote healthy human ageing through reduced age-associated inflammation and improved aged lymphocyte function.