Microscopic Scooping for Unbiased, Subcellular, Spatial Optoproteomic Discovery 

Host: Tony Ly

Venue: Sir Kenneth & Lady Noreen Murray Seminar Room, CTIR 2.84

Abstract

The quest for unbiased spatial proteomic discovery is critical in understanding the complex microenvironments within biological tissues. Traditional methods like proximity labelling and Laser Capture Microdissection (LCM) have their limitations: proximity labelling suffers from sample restriction (non-human models) and can lead to biased results due to incomplete labelling, while LCM is laborious and often lacks the precision needed for single-cell resolution.

• Introduction to the SynCell Microscoop Mint: Discover its groundbreaking features and benefits along with a workflow overview.
• Functional Biology Examples: Explore how the Microscoop Mint is being applied in diverse fields such as:
• Cell biology
• Neurodegenerative disease
• Drug discovery
• Immuno-oncology

• Developmental biology

   

• Technical Insights: Learn how Microscoop Mint achieves spatial protein purification by introducing in situ subcellular photo-biotinylation of proteins at user-defined regions of interest (ROIs) one field of view (FOV) at a time for thousands of FOVs fully automatically. With mass spectrometry, Microscoop enables the discovery of subcellular proteomes in high sensitivity, specificity, and resolution.

Matteo Cattaneo, Field Application Specialist, will be presenting in person. Matteo's kindly agreed to stay after his seminar and would be happy to meet anyone who is interested in learning more about the technology. Please register your interest here. https://go.syncell.com/seminar-dundee