"Rewiring and Reconstituting Eukaryotic Cytokinesis"

Host: Professor Mike Ferguson

Venue: MSI Large Lecture Theatre, SLS

Abstract:

Cytokinesis in many eukaryotes requires a force generating contractile actomyosin ring (CAR).  Work carried in my group over ~ three decades, using Schizosaccharomyces pombe, which we established as a model for uncovering mechanisms of eukaryotic cytokinesis, has led to the identification of components of the CAR and elucidated mechanisms of how they assemble into a contractile apparatus, how and when they constrict, and how constriction is coupled with assembly of new membranes and division septum. In the recent years, we have been investigating the precise mechanisms of force generation using a combination of advanced imaging, genetics, biophysics, and structural biology.  I will describe the recent work from the group, placing them in the broader context of the field of eukaryotic cytokinesis.

ALL WELCOME