An Anatomical study of Trigeminal Nerve and its structural relations

The trigeminal nerve (CN V) is the largest and thickest of all cranial nerves. It connects to the trigeminal ganglion and then divides into three branches: the ophthalmic (V1), maxillary (V2), and mandibular (V3) nerves. The trigeminal nerve gathers sensory information from a significant portion of the scalp, teeth, and the oral and nasal cavities. It provides sensations to the face and branches off into motor pathways that control the chewing muscles. The orofacial region is one of the most common areas of the body where pain occurs. Chronic orofacial pain can result from either damage to the trigeminal or central nervous system (neuropathic pain) or from the activation of nociceptors (nociceptive pain). Trigeminal neuralgia is a condition marked by sudden, sharp bursts of pain that can last from seconds to minutes. According to available data, spontaneous pressure of the trigeminal nerve at its root entrance zone is the most frequent cause of this orofacial pain. This is primarily linked to smaller trigeminal nerves and a reduced number of nerve fibres, which is believed to cause brief episodes of sharp, shooting pain. Not much research has been done on the architecture of the trigeminal nerve and its link to trigeminal neuropathy. Focussing on the trigeminal nerve, however, may be a viable therapy strategy for these individuals due to the possibility of trigeminal nerve alterations. The study will aim to see the structure and anatomical relations of the neighbouring structures with the trigeminal nerve. This may assist in determining the pathogenesis of trigeminal neuralgia.

Diversity statement

Our research community thrives on the diversity of students and staff which helps to make the University of Dundee a UK university of choice for postgraduate research.  We welcome applications from all talented individuals and are committed to widening access to those who have the ability and potential to benefit from higher education.