Pharmacological intervention of redox signalling in the regulation of anti-angiogenic factors in cardiovascular disease using in vivo imaging techniques

Oxidative stress is explicitly linked with cardiovascular disease. Oxidative modifications of proteins termed redox signalling induce changes in protein function, location and stability. This project will investigate the pharmacological intervention of redox signalling using cutting edge cardiovascular imaging techniques including ultrasound and echocardiography to measure vascular stiffness and cardiac function.

By using a combination of different pharmacology interventions and genetically modification we will uncover the impact of redox signalling on endothelial function in the setting of gestational hypertension and diabetes. Subsequently pathological assessment of key organs (kidney, heart, placenta) will take place to investigate the underpinning disease. In addition, this project will utilise stem cell technology to model pathological conditions in combination with this emerging organ-on-a-chip technology to assess pharmacology intervention of redox signalling in endothelial function via regulation of anti-angiogenic factors.

This translational project will enable the student to conduct in vivo cardiovascular pre-clinical modelling in combination to interrogate molecular pathways involved in cardiovascular disease.

Looking for candidates with an interest in preclinical research

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Our research community thrives on the diversity of students and staff which helps to make the University of Dundee a UK university of choice for postgraduate research. We welcome applications from all talented individuals and are committed to widening access to those who have the ability and potential to benefit from higher education.