Centre for Targeted Protein Degradation
The Centre for Targeted Protein Degradation (CeTPD) is bolstering the University of Dundee’s world-leading position in a field that is revolutionising drug discovery.
Targeted protein degradation
Targeted protein degradation co-opts the cell’s natural disposal systems to remove disease-causing proteins and is applicable to diverse therapeutic areas including oncology, dermatology, immunology, neuroscience and respiratory diseases. This entirely new approach is revolutionising drug discovery by making the treatment of diseases previously thought to be undruggable a reality.
CeTPD is part of the University’s School of Life Sciences, one of the UK’s top institutions for research into biological sciences.
Dundee researchers and teams led by Professor Alessio Ciulli have previously revealed fundamental insights into the working of the degrader molecules that they have designed and that are used across the globe. Collaborations with pharma companies Boehringer Ingelheim and Almirall amongst others are helping to advance the field, while the biopharmaceutical company Amphista Therapeutics is a University of Dundee spin-out of the Ciulli Lab.
Our new translational research centre will build on this established excellence to innovate groundbreaking science and accelerate translation by developing and inspiring the next generation of scientists and leaders.
Stories
Press release
A University of Dundee scientist whose pioneering work holds promise for developing new treatments for “undruggable” diseases has been elected a Fellow of the Royal Society (FRS), one of the highest honours for any scientist
Press release
Ground-breaking drug discovery work at the University of Dundee has been honoured by a major international award.
News
The top three most ordered molecules on opnMe in 2024 have one thing in common. They all emerged from a research collaboration between the Centre of Targeted Protein Degradation (CeTPD) at the University of Dundee and Boehringer Ingelheim.
Press release
A innovative molecular “cut and sew” process by University of Dundee scientists has allowed the design of a research tool that will accelerate drug design for diseases for which no other options exist, including cancer.
Press release
Dundee researchers have revealed in the greatest detail yet the workings of molecules called ‘protein degraders’ which can be deployed to combat what have previously been regarded as ‘undruggable’ diseases, including cancers and neurodegenerative diseases
Press release
Experts from the University’s Centre for Targeted Protein Degradation (CeTPD), working with Boehringer Ingelheim scientists, have developed a breakthrough small-molecule drug, a “protein degrader”.
News
Four early career researchers have been awarded fellowships that will allow them to join laboratories in the School of Life Sciences.
Press release
One of Scotland’s most significant scientific success stories in recent times has been celebrated at a special event hosted by the University of Dundee.
